We've recently had a question asking whether a certain technological explanation in a manga is valid. This currently has 2 close votes (one mine, though I was somewhat on the fence). The reason left on the post is the following:
This question appears to be off-topic because it is about computers/technology. Even though this happened in a manga, asking whether it's possible IRL is outside of the scope of this site.
That leads to the question: Is there any valid question for this site of the form "X happened in anime/manga Y. Is this actually possible/could it happen in real life?" or "X was explained in anime/manga Y. Is this explanation correct?"? What about the closely related category of questions of the form "What are the real-world inspirations for X in anime/manga Y?"? Can we issue a blanket ban on all questions like this, or are there cases that we want to keep around?
This was discussed before specifically about cultural questions: Where should we draw the line with "culture" questions?, but this question is about all types of questions, not just culture. The conclusion was that, in the case of cultural questions, the question needs to be specific to anime/manga. If it still makes sense with all references to anime/manga removed, then it's off topic.
For what it's worth, I've seen a couple of questions like this on Scifi SE, for example: How “hard” is the science behind the genetics mentioned in Blade Runner?. I could see similar questions getting asked about popular scifi anime here like Steins;Gate or Planetes.